In 2019,Journal of the American Chemical Society included an article by Phelan, James P.; Lang, Simon B.; Sim, Jaehoon; Berritt, Simon; Peat, Andrew J.; Billings, Katelyn; Fan, Lijun; Molander, Gary A.. Synthetic Route of C7H5BrO2. The article was titled 《Open-Air Alkylation Reactions in Photoredox-Catalyzed DNA-Encoded Library Synthesis》. The information in the text is summarized as follows:
DNA-encoded library (DEL) technol. is a powerful tool commonly used by the pharmaceutical industry for the identification of compounds with affinity to biomol. targets. Success in this endeavor lies in sampling diverse chem. libraries. However, current DELs tend to be deficient in C(sp3) carbon counts. The authors report unique solutions to the challenge of increasing both the chem. diversity of these libraries and their C(sp3) carbon counts by merging Ni/photoredox dual catalytic C(sp2)-C(sp3) cross-coupling as well as photoredox-catalyzed radical/polar crossover alkylation protocols with DELs. The successful integration of multiple classes of radical sources enables the rapid incorporation of a diverse set of alkyl fragments. In the experimental materials used by the author, we found 4-Bromobenzoic acid(cas: 586-76-5Synthetic Route of C7H5BrO2)
4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Synthetic Route of C7H5BrO2 It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary