In 2010,Payne, Sara L.; Rodriguez-Aristegui, Sonsoles; Bardos, Julia; Cano, Celine; Golding, Bernard T.; Hardcastle, Ian R.; Peacock, Marcus; Parveen, Nahida; Griffin, Roger J. published 《Mapping the ATP-binding domain of DNA-dependent protein kinase (DNA-PK) with coumarin- and isocoumarin-derived inhibitors》.Bioorganic & Medicinal Chemistry Letters published the findings.Recommanded Product: 3-Bromo-2-methylbenzoic acid The information in the text is summarized as follows:
Replacement of the core heterocycle of a defined series of chromen-4-one DNA-PK inhibitors by the isomeric chromen-2-one (coumarin) and isochromen-1-one (isocoumarin) scaffolds was investigated. Structure-activity relationships for DNA-PK inhibition were broadly consistent, albeit with a reduction of potency compared with the parent chromenone. In the experiment, the researchers used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Recommanded Product: 3-Bromo-2-methylbenzoic acid)
3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Recommanded Product: 3-Bromo-2-methylbenzoic acid
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary