Morozumi, Akihiko’s team published research in Journal of the American Chemical Society in 2020 | CAS: 2623-87-2

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Recommanded Product: 2623-87-2

《Spontaneously Blinking Fluorophores Based on Nucleophilic Addition/Dissociation of Intracellular Glutathione for Live-Cell Super-resolution Imaging》 was written by Morozumi, Akihiko; Kamiya, Mako; Uno, Shin-nosuke; Umezawa, Keitaro; Kojima, Ryosuke; Yoshihara, Toshitada; Tobita, Seiji; Urano, Yasuteru. Recommanded Product: 2623-87-2 And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

Single-mol. localization microscopy (SMLM) allows the reconstruction of super-resolution images but generally requires prior intense laser irradiation and in some cases additives to induce blinking of conventional fluorophores. The authors previously introduced a spontaneously blinking rhodamine fluorophore based on an intramol. spirocyclization reaction for live-cell SMLM under physiol. conditions. Here, the authors report a novel principle of spontaneous blinking in living cells, which utilizes reversible ground-state nucleophilic attack of intracellular glutathione (GSH) upon a xanthene fluorophore. Structural optimization afforded two pyronine fluorophores with different colors, both of which exhibit equilibrium (between the fluorescent dissociated form and the nonfluorescent GSH adduct form) and blinking kinetics that enable SMLM of microtubules or mitochondria in living cells. Furthermore, by using spontaneously blinking fluorophores working in the near-IR (NIR) and green ranges, the authors succeeded in dual-color live-cell SMLM without the need for optimization of the imaging medium. In the experiment, the researchers used many compounds, for example, 4-Bromobutanoic acid(cas: 2623-87-2Recommanded Product: 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Recommanded Product: 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary