Miyamoto, Shoto; Matsuoka, Aki; Yamada, Yuji; Ishikawa, Ryuta; Hayashida, Osamu published the artcile< Benzoxaborole Catalyst for Site-Selective Modification of Polyols>, Application In Synthesis of 6942-39-8, the main research area is benzoxaborole catalyst preparation; site selective protecting group free modification polyol; benzoylation tosylation benzylation glycosylation cis diol benzoxaborole catalyst.
The site-selective modification of polyols bearing several hydroxyl groups without the use of protecting groups remains a significant challenge in synthetic chem. To address this problem, novel benzoxaborole derivatives were designed as efficient catalysts for the highly site-selective and protecting-group-free modification of polyols. To identify the effective substituent groups enhancing the catalytic activity and selectivity, a series of benzoxaborole catalysts were synthesized. In-depth anal. for the substituent effect revealed that I [R = 4-F, 4-CF3, 3,5-(CF3)2], bearing multiple electron-withdrawing fluoro- and trifluoromethyl groups, exhibited the greatest catalytic activity and selectivity. Moreover, I [R = 4-F]-catalyzed benzoylation, tosylation, benzylation, and glycosylation of various cis-1,2-diol derivatives proceeded with good yield and site-selective manner.
European Journal of Organic Chemistry published new progress about Benzoxaboroles Role: CAT (Catalyst Use), SPN (Synthetic Preparation), USES (Uses), PREP (Preparation). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Application In Synthesis of 6942-39-8.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary