In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Liu, Lin; Lei, Lin-Sheng; Zhan, Zong-Song; Liu, Si-Zhan; Wang, Yu-Xiao; Tu, Yong-Qiang; Zhang, Fu-Min; Zhang, Xiao-Ming; Ma, Ai-Jun; Wang, Shao-Hua. Category: bromides-buliding-blocks. The article was titled 《A catalytic asymmetric one-pot [3+2] cyclization/semipinacol rearrangement sequence: an efficient construction of a multi-substituted 3H-spiro[benzofuran-2,1′-cyclopentane] skeleton》. The information in the text is summarized as follows:
A facile and efficient method to form a chiral multi-substituted 3H-spiro[benzofuran-2,1′-cyclopentane] structural unit was developed via a one-pot [3+2] cycloaddition/semipinacol rearrangement cascade. A catalysis system of Cu(II)/BOX was used to efficiently construct a key stereogenic center via a cyclization between substituted benzoquinones and allylic alcs. afforded the desired products in good yields and with excellent enantioselectivities and diastereoselectivities (21 examples; up to 67% yields; up to 92% ee and up to >20 : 1 dr). This method provided an alternative strategy for the synthesis of the corresponding bioactive mols. containing spiro[benzofurancyclopentane] skeleton units. In the experimental materials used by the author, we found (Bromomethyl)cyclopropane(cas: 7051-34-5Category: bromides-buliding-blocks)
(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary