Liu, Jingbo; Shi, Yabing; Chen, Shuting; Li, Fengyun; Wen, Wen; Wang, Yuanhong published the artcile< Discovery of evodiamine derivatives as potent insecticide candidates>, SDS of cas: 20776-50-5, the main research area is evodiamine derivative Mythimna Plutella Helicoverpa larvicide; Evodiamine; Insecticidal activity; Mode of action; Structure activity relationships.
In the search for novel more effective insecticides, natural products could be used as ideal template compounds due to their good environmental compatibility, various bioactivities, unique scaffolds and mode of action. We have found that natural product evodiamine, the main active component from the fruits of Evodia rutaecarpa (Juss.) Benth, displayed obvious insecticidal activities against lepidoptera pests. To continue our research, a series of evodiamine derivatives 3a-3aa were rationally designed and synthesized. The larvicidal activities results indicated that most of target compounds displayed better efficacy than evodiamine, matrine, and rotenone against Mythimna separata, Plutella xylostella and Helicoverpa armigera, among which 3z exhibited excellent larvicidal activities (65% at 2.5 mg/L against M. separata, 75% at 1.0 mg/L against P. xylostella, and 85% 10 mg/L against H. armigera, resp.), much better than evodiamine (0%), matrine (0%), and rotenone (0%). The preliminary structure activity relationships demonstrated that the fluorine atom at the E ring of evodiamine had a pos. influence on the larvicidal activity. The calcium imaging experiment studies indicated that 3z could act on the ryanodine receptor (RyR) of M. separata and was an effective calcium activator for RyR.
Bioorganic & Medicinal Chemistry published new progress about Endoplasmic reticulum. 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, SDS of cas: 20776-50-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary