Product Details of 583-69-7On May 31, 2019, Li, Yang-Yang; Liu, Hong; Xu, Ying; Zhou, Ning-Yi published an article in International Biodeterioration & Biodegradation. The article was 《A two-component monooxygenase initiates a novel 2-bromo-4-nitrophenol catabolic pathway in newly isolated Cupriavidus sp. strain NyZ375》. The article mentions the following:
As a vital byproduct of chem. intermediates for pesticides and cytotoxin inhibitors, 2-bromo-4-nitrophenol (2B4NP) is toxic to aquatic life. However, bacterial cultures mineralizing 2B4NP have not been reported. In this study, Cupriavidus sp. strain NyZ375 was isolated from aromatics-polluted soil and identified by 16S rRNA gene sequencing. Via an oxidative pathway, it grows on 120μM 2B4NP as the only carbon source, releasing approx. equivalent amount of nitrite. Three genes (bnpABC) in a 4.8-kb DNA fragment from a draft genome was found to be responsible for the initial reactions in 2B4NP degradation BnpAB are the monooxygenase and flavin reductase components, resp., catalyzing the monooxygenation of 2B4NP to bromohydroquinone (BHQ, 63%) and 1,2,4-benzenetriol (BT, 37%) with concomitant nitrite release, in the presence of NADH and FAD. BnpC is a hydroxyquinol 1,2-dioxygenase catalyzing the ring-cleavage oxidation of BT to maleylacetate. The byproduct BHQ was not further degraded by strain NyZ375 but was not toxic to its growth at a concentration of 100μM. It can be tentatively concluded that BnpAB is evolutionary close to the 2,4,6-trichlorophenol monooxygenase TcpAX from Cupriavidus necator JMP134. The 2B4NP catabolism by this new isolate illustrates a pathway distinct from those of all identified 2-chloro-4-nitrophenol utilizers. In addition to this study using 2-Bromobenzene-1,4-diol, there are many other studies that have used 2-Bromobenzene-1,4-diol(cas: 583-69-7Product Details of 583-69-7) was used in this study.
2-Bromobenzene-1,4-diol(cas: 583-69-7) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.Product Details of 583-69-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary