Reference of Methyl 3-(bromomethyl)benzoateIn 2017 ,《Design and synthesis of a series of L-trans-4-substituted prolines as selective antagonists for the ionotropic glutamate receptors including functional and X-ray crystallographic studies of new subtype selective kainic acid receptor subtype 1 (Gluk1) antagonist (2S,4R)-4-(2-carboxyphenoxy)pyrrolidine-2-carboxylic acid》 appeared in Journal of Medicinal Chemistry. The author of the article were Krogsgaard-Larsen, Niels; Delgar, Claudia G.; Koch, Karina; Brown, Patricia M. G. E.; Moeller, Charlotte; Han, Liwei; Huynh, Tri H. V.; Hansen, Stinne W.; Nielsen, Birgitte; Bowie, Derek; Pickering, Darryl S.; Kastrup, Jette Sandholm; Frydenvang, Karla; Bunch, Lennart. The article conveys some information:
Ionotropic glutamate receptor antagonists are valuable tool compounds for studies of neurol. pathways in the central nervous system. On the basis of rational ligand design, a new class of selective antagonists, represented by (2S,4R)-4-(2-carboxyphenoxy)pyrrolidine-2-carboxylic acid (I), for cloned homomeric kainic acid receptors subtype 1 (GluK1) was attained (Ki = 4 μM). In a functional assay, I displayed full antagonist activity with IC50 = 6 ± 2 μM. A crystal structure was obtained of I when bound in the ligand binding domain of GluK1. A domain opening of 13-14° was seen compared to the structure with glutamate, consistent with I being an antagonist. A structure-activity relationship study showed that the chem. nature of the tethering atom (C, O, or S) linking the pyrrolidine ring and the Ph ring plays a key role in the receptor selectivity profile and that substituents on the Ph ring are well accommodated by the GluK1 receptor. The experimental process involved the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Reference of Methyl 3-(bromomethyl)benzoate)
Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Organobromine compounds are produced naturally by marine creatures (sponges, corals, sea slugs, tunicates, sea fans) and seaweed, plants, fungi, lichen, algae, bacteria, microbes, and some mammals. Reference of Methyl 3-(bromomethyl)benzoate
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Bromide – Wikipedia,
bromide – Wiktionary