Kretschmer, Nadine; Hufner, Antje; Durchschein, Christin; Popodi, Katrin; Rinner, Beate; Lohberger, Birgit; Bauer, Rudolf published an article in 2021. The article was titled 《Synthesis and pharmacological in vitro investigations of novel shikonin derivatives with a special focus on cyclopropane bearing derivatives》, and you may find the article in International Journal of Molecular Sciences.Application of 2623-87-2 The information in the text is summarized as follows:
In previous studies, author’s showed that the constituents of the roots of Onosma paniculata as well as a synthetic derivative of the most active constituent showed promising results in metastatic melanoma cell lines. In the current study, author’s address the question whether author’s can generate further derivatives with optimized activity by synthesis. Therefore, author’s prepared 31, mainly novel shikonin derivatives and screened them in different melanoma cell lines (WM9, WM164, and MUG-Mel2 cells) using the XTT viability assay. Author’s identified (R)-1-(1,4-dihydro-5,8-dihydroxy-1,4-dioxonaphthalen-2-yl)-4-methylpent-3-enyl 2-cyclopropyl-2-oxoacetate as a novel derivative with even higher activity. Furthermore, pharmacol. investigations including the ApoToxGloM Triplex assay, LDH assay, and cell cycle measurements revealed that this compound induced apoptosis and reduced cells in the G1 phase accompanied by an increase of cells in the G2/M phase. Moreover, it showed hardly any effects on the cell membrane integrity. However, it also exhibited cytotoxicity against non-tumorigenic cells. Nevertheless, in summary, author’s could show that shikonin derivatives might be promising drug leads in the treatment of melanoma. In the experimental materials used by the author, we found 4-Bromobutanoic acid(cas: 2623-87-2Application of 2623-87-2)
4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Application of 2623-87-2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary