Kircher, Theresa; Pantsar, Tatu; Oder, Andreas; Peter von Kries, Jens; Juchum, Michael; Pfaffenrot, Bent; Kloevekorn, Philip; Albrecht, Wolfgang; Selig, Roland; Laufer, Stefan published an article in 2021. The article was titled 《Design and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4》, and you may find the article in European Journal of Medicinal Chemistry.SDS of cas: 586-76-5 The information in the text is summarized as follows:
The azaindole-based scaffold of FDA-approved BRAF inhibitor vemurafenib 1, which displays off-target activity on mitogen-activated protein kinase kinase 4 (MKK4), as a starting point in fluorescent compound design was utilized. Chem. variation of the scaffold and optimization led to a selection of fluorescent 5-TAMRA derivatives I (R = Pr, benzyl; R1 = -NHC(O)-, -C(O)NH-; X = CH; Y = N, CH; n = 1, 4), II (R = n-propyl; R1 = -NHC(O)-, -C(O)NH-; X = CH, N; Y = CH, N; n = 1-6) which possess high binding affinities on MKK4. Compound II (R = n-propyl; R1 = -NHC(O)-; X = CH; Y = N; n = 4) represents a suitable tool compound for fluorescence polarization assays to identify new small-mol. inhibitors of MKK4.4-Bromobenzoic acid(cas: 586-76-5SDS of cas: 586-76-5) was used in this study.
4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.SDS of cas: 586-76-5 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary