The author of 《Palladium-Catalyzed Construction of Quaternary Stereocenters by Enantioselective Arylation of γ-Lactams with Aryl Chlorides and Bromides》 were Jette, Carina I.; Geibel, Irina; Bachman, Shoshana; Hayashi, Masaki; Sakurai, Shunya; Shimizu, Hideki; Morgan, Jeremy B.; Stoltz, Brian M.. And the article was published in Angewandte Chemie, International Edition in 2019. Synthetic Route of C7H4BrF3 The author mentioned the following in the article:
The first Pd-catalyzed enantioselective arylation of α-substituted γ-lactams were reported. Two sets of conditions were developed for this transformation, allowing for the use of either aryl chlorides or bromides as electrophiles. Utilizing a highly electron-rich dialkylphosphine ligand, α-quaternary centers in good yields (up to 91% yield) and high enantioselectivities (up to 97% ee) was constructed.1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7Synthetic Route of C7H4BrF3) was used in this study.
1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Synthetic Route of C7H4BrF3 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary