《Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT1A/5-HT7 receptor antagonists and phosphodiesterase 4/7 inhibitors with procognitive and antidepressant activity》 was published in European Journal of Medicinal Chemistry in 2020. These research results belong to Jankowska, Agnieszka; Satala, Grzegorz; Kolaczkowski, Marcin; Bucki, Adam; Gluch-Lutwin, Monika; Swierczek, Artur; Pociecha, Krzysztof; Partyka, Anna; Jastrzebska-Wiesek, Magdalena; Lubelska, Annamaria; Latacz, Gniewomir; Gawalska, Alicja; Bojarski, Andrzej J.; Wyska, Elzbieta; Chlon-Rzepa, Grazyna. HPLC of Formula: 2969-81-5 The article mentions the following:
A library of novel anilide and benzylamide derivatives of ω-(4-(2-methoxyphenyl)piperazin-1-yl)alkanoic acids as combined 5-HT1A/5-HT7 receptor ligands and phosphodiesterase PDE4B/PDE7A inhibitors was designed using a structure-based drug design approach. The in vitro studies of 33 newly synthesized compounds (7-39) allowed us to identify 22 as the most promising multifunctional 5-HT1A/5-HT7 receptor antagonist (5-HT1AKi = 8 nM, Kb = 0.04 nM; 5-HT7Ki = 451 nM, Kb = 460 nM) with PDE4B/PDE7A inhibitory activity (PDE4B IC50 = 80.4μM; PDE7A IC50 = 151.3μM). Compound 22 exerted a very good ability to passively penetrate through biol. membranes and a high metabolic stability in vitro. Moreover, the pharmacol. evaluation of 22 showed its procognitive and antidepressant properties in rat behavioral tests. Compound 22 at a dose of 3 mg/kg (i.p.) significantly reversed MK-801-induced episodic memory deficits in the novel object recognition test, while at a dose of 10 mg/kg (i.p.) reduced the immobility time of animals (by about 34%) in the forced swimming test. The antidepressant-like effect produced by compound 22 was stronger than that of escitalopram used as a reference drug. This study opens a new perspective in the search for efficacious drugs for the treatment of cognitive and depressive disorders. In the part of experimental materials, we found many familiar compounds, such as Ethyl 4-bromobutyrate(cas: 2969-81-5HPLC of Formula: 2969-81-5)
Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.HPLC of Formula: 2969-81-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary