Huang, Shuai Shuai; Zheng, Zhan Jiang; Cui, Yu Ming; Xu, Zheng; Yang, Ke Fang; Xu, Li Wen published the artcile< Convenient Synthesis of 2-(2,2-Difluoroethoxy)-6-(trifluoromethyl)-benzenesulfonyl Chloride, A Key Building Block of Penoxsulam>, Formula: C7H4BrF3, the main research area is difluoroethoxy trifluoromethyl benzenesulfonyl chloride preparation key building block penoxsulam; bromobenzotrifluoride regioselective lithiation coupling chloroxidn copper catalyst.
A convenient and efficient three-step synthesis of 2-(2,2-difluoroethoxy)-6-(trifluoromethyl)benzenesulfonyl chloride, the key building block of penoxsulam, is described. The main features of the synthesis include a regioselective lithiation and subsequent electrophilic substitution starting from com. available 3-bromobenzotrifluoride to provide (2-bromo-6-(trifluoromethyl)phenyl)(propyl)sulfane, then a copper-catalyzed C-O coupling to introduce the difluoroethoxy moiety and chloroxidn. conditions to give the desired sulfonyl chloride.
Synthesis published new progress about Arenesulfonyl chlorides Role: SPN (Synthetic Preparation), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Formula: C7H4BrF3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary