Hu, Xiao-Qian; Han, Jia-Bin; Zhang, Cheng-Pan published the artcile< Cu-Mediated Trifluoromethylation of Aromatic α-Diazo Esters with the Yagupolskii-Umemoto Reagent>, Electric Literature of 14062-30-7, the main research area is aromatic diazo ester trifluoromethylation Yagupolskii Umemoto reagent copper; trifluoromethyl arylacetic ester preparation; copper trifluoromethylation catalyst.
Reductive trifluoromethylation of aromatic α-diazo esters at room temperature with the Yagupolskii-Umemoto reagent {[Ph2SCF3][OTf]; (I)} in DMF in the presence of excess CuCl gave a variety of α-trifluoromethyl arylacetates, e.g., II, in up to 93 % yield. The prior reaction of I with CuCl before the addition of the α-diazo esters was imperative for the conversion. This initial reaction might pregenerate the key [CuICF3] intermediate, according to the results of our control experiments When the long-chain perfluoroalkyl diphenylsulfonium triflates were used instead of I, the reaction of an aromatic α-diazo ester under the same conditions followed by treatment with NaHCO3 gave a series of fluorinated α,β-unsaturated esters in good yields. This protocol gives a facile, convenient, and practical access to α-trifluoromethyl arylacetates and their analogs, implying that the “”+Rfn”” reagents are compatible with α-diazo esters in the presence of an appropriate reductant.
European Journal of Organic Chemistry published new progress about Esters Role: RCT (Reactant), RACT (Reactant or Reagent) (α-diazo). 14062-30-7 belongs to class bromides-buliding-blocks, and the molecular formula is C10H11BrO2, Electric Literature of 14062-30-7.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary