Han, Xiao-Qing; Wang, Lei; Yang, Ping; Liu, Jing-Yuan; Xu, Wei-Yan; Zheng, Chao; Liang, Ren-Xiao; You, Shu-Li; Zhang, Junliang; Jia, Yi-Xia published the artcile< Enantioselective Dearomative Mizoroki-Heck Reaction of Naphthalenes>, Recommanded Product: 2-Bromo-4-isopropylaniline, the main research area is naphthoylamino bromoarene palladium catalyst enantioselective dearomative Mizoroki Heck reaction; spirooxindole naphthalene preparation; bromobenzoyl naphthylamine palladium catalyst enantioselective dearomative Mizoroki Heck reaction; spiro oxoisoindoline naphthalene preparation.
A palladium-catalyzed intramol. enantioselective Mizoroki-Heck reaction of naphthalenes was developed via dearomative migratory insertion of an endocyclic π-bond of naphthalene, followed by δ-hydride elimination. This reaction relies on the use of chiral sulfonamide phosphine type Xu-Phos ligand, which successfully inhibited the competitive and undesired C-H arylation reaction and efficiently promoted the formation of spirooxindole and spiroisoindolin-1-one products. Synthetic transformations of the product afforded a series of unique heterocyclic compounds with enantiomeric excess (ee) values retained.
ACS Catalysis published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 51605-97-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H12BrN, Recommanded Product: 2-Bromo-4-isopropylaniline.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary