Ghosh, Arghya; Barik, Soumen; Biju, Akkattu T. published the artcile< NHC-Catalyzed [3 + 3] Annulation of Thioamides and Modified Enals for the Enantioselective Synthesis of Functionalized Thiazinones>, SDS of cas: 3893-18-3, the main research area is thiazinone preparation enantioselective; thioamide bromoenal thia Michael addition intramol cyclization.
N-Heterocyclic carbene (NHC)-catalyzed [3 + 3] annulation of thioamides with modified enals allowing the enantioselective synthesis of functionalized 1,3-thiazin-4-ones is reported. The NHC generated from the chiral triazolium salt was optimal and the reaction is initiated by the thia-Michael addition to catalytically generated α,β-unsaturated acylazolium intermediates derived from 2-bromoenals, followed by intramol. cyclization. This operationally simple procedure offers a straightforward and rapid access to target compounds in moderate to good yields and enantiomeric ratio values.
Organic Letters published new progress about Cyclization catalysts, stereoselective ([3 + 3]). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, SDS of cas: 3893-18-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary