Friis, Stig D.; Pirnot, Michael T.; Dupuis, Lauren N.; Buchwald, Stephen L. published the artcile< A Dual Palladium and Copper Hydride Catalyzed Approach for Alkyl-Aryl Cross-Coupling of Aryl Halides and Olefins>, Recommanded Product: (3-Bromophenyl)(trifluoromethyl)sulfane, the main research area is palladium copper hydride catalyzed cross coupling aryl halide olefin; alkenes; copper; cross-coupling; homogeneous catalysis; palladium.
We report an efficient means of sp2-sp3 cross coupling for a variety of terminal monosubstituted olefins with aryl electrophiles using Pd and CuH catalysis [e.g., 4-bromoanisole + 4-phenyl-1-butene → MeOC6H4-4-(CH2)4Ph in presence of [Pd(cinnamyl)Cl]2, BrettPhos, CuCl.(R)-DTBM-SEGPHOS and Me2PhSiH]. In addition to its applicability to a range of aryl bromide substrates, this process was also suitable for electron-deficient aryl chlorides, furnishing higher yields than the corresponding aryl bromides in these cases. The optimized protocol does not require the use of a glove-box and employs air-stable Cu and Pd complexes as precatalysts. A reaction on 10 mmol scale further highlighted the practical utility of this protocol. Employing a similar protocol, a series of cyclic alkenes were also examined Cyclopentene was shown to undergo efficient coupling under these conditions. Lastly, deuterium-labeling studies indicate that deuterium scrambling does not take place in this sp2-sp3 cross coupling, implying that β-hydride elimination is not a significant process in this transformation.
Angewandte Chemie, International Edition published new progress about Aryl bromides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2252-45-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3S, Recommanded Product: (3-Bromophenyl)(trifluoromethyl)sulfane.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary