Fernandez, Maitane; Uria, Uxue; Vicario, Jose L.; Reyes, Efraim; Carrillo, Luisa published the artcile< Enantioselective Conjugate Addition of Donor-Acceptor Hydrazones to α,β-Unsaturated Aldehydes through Formal Diaza-Ene Reaction: Access to 1,4-Dicarbonyl Compounds>, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde, the main research area is donor acceptor hydrazone enal conjugate addition formal diaza ene; conjugate addition adduct hydride shift oxidation; carboxylic acid gamma hydrazono stereoselective organocatalytic preparation; dicarbonyl stereoselective preparation.
Donor-acceptor monosubstituted hydrazones participate as suitable reagents able to undergo an enantioselective formal diaza-ene reaction with α,β-unsaturated aldehydes under chiral secondary amine catalysis. This constitutes a new approach for the enantioselective conjugate addition of hydrazones to enals under metal-free conditions and leads to the formation of γ-hydrazono carboxylic acids after oxidation/[1,3]-H shift. The methodol. is also useful for the synthesis of enantioenriched β-substituted α-keto-1,5-diesters by using the hydrazone moiety as a masked carbonyl group.
Journal of the American Chemical Society published new progress about Aliphatic acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (γ-hydrazono). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary