Farizyan, Mirxan; Mondal, Arup; Mal, Sourjya; Deufel, Fritz; van Gemmeren, Manuel published their research in Journal of the American Chemical Society in 2021. The article was titled 《Palladium-Catalyzed Nondirected Late-Stage C-H Deuteration of Arenes》.Computed Properties of C9H11Br The article contains the following contents:
Herein, palladium catalyzed nondirected late-stage deuteration of arenes is discussed. Key aspects include the use of D2O as a convenient and easily available deuterium source and the discovery of highly active N,N-bidentate ligands containing an N-acyl sulfonamide group. The reported protocol enables high degrees of deuterium incorporation via a reversible C-H activation step and features an extraordinary functional group tolerance, allowing for the deuteration of complex substrates. This is exemplified by the late-stage isotopic labeling of various pharmaceutically relevant motifs and related scaffolds. This method, among other applications, will prove useful as a tool in drug development processes and for mechanistic studies. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Computed Properties of C9H11Br)
1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Computed Properties of C9H11Br Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary