In 1952,Journal of the American Chemical Society included an article by Erickson, J. L. E.; Dechary, J. M.; Pullig, T. R.. Synthetic Route of C7H4BrNO4. The article was titled 《Bromo-2-nitrobenzoic acids》. The information in the text is summarized as follows:
Synthetic methods of preparation for the 4 isomeric bromo-2-nitrobenzoic acids are described. 3-Bromo-2-nitrobenzoic acid was prepared by deamination of a new compound, 5-bromo-6-nitroanthranilic acid, m. 201-2.5° [from bromination of 6,2-O2N(H2N)C6H3CO2H]. The synthesis of 4-bromo-2-nitrobenzoic acid was accomplished by the hydrolysis of 4-bromo-2-nitrobenzonitrile and also by the oxidation of 4-bromo-2-nitrotoluene. 5-Bromo-2-nitrobenzoic acid was prepared by the nitration of m-bromobenzoic acid, an old method. 6-Bromo-2-nitrobenzoic acid, m. 177.3-7.5°, a new compound, was obtained in excellent yield from 6-nitroanthranilic acid. After reading the article, we found that the author used 3-Bromo-2-nitrobenzoic acid(cas: 116529-61-4Synthetic Route of C7H4BrNO4)
3-Bromo-2-nitrobenzoic acid(cas: 116529-61-4) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Synthetic Route of C7H4BrNO4 Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary