Epperson, James R.; Bruce, Marc A.; Catt, John D.; Deskus, Jeffrey A.; Hodges, Donald B.; Karageorge, George N.; Keavy, Daniel J.; Mahle, Cathy D.; Mattson, Ronald J.; Ortiz, Astrid A.; Parker, Michael F.; Takaki, Katherine S.; Watson, Brett T.; Yevich, Joseph P. published the artcile< Chronobiotic activity of N-[2-(2,7-dimethoxyfluoren-9-yl)ethyl]-propanamide. Synthesis and melatonergic pharmacology of fluoren-9-ylethyl amides>, Reference of 6942-39-8, the main research area is melatonin receptor agonist methoxy fluorenylethyl propanamide preparation chronobiotic; structure activity melatonin receptor methoxy fluorenylethyl propanamide preparation chronobiotic; biol rhythm chronobiotic methoxy fluorenylethyl amide preparation human.
A series of fluoren-9-yl Et amides were synthesized and evaluated for human melatonin MT1 and MT2 receptor binding. N-[2-(2,7-dimethoxy-9H-fluoren-9-yl)ethyl]propanamide (I) was selected and evaluated in functional assays measuring intrinsic activity at the human MT1 and MT2 receptors and demonstrated full agonism at both receptors. The chronobiotic properties of I were demonstrated in both acute and chronic rat models where I produced an acute phase advance of 32 min at 1 mg/kg and chronically entrained free-running rats with a mean ED of 0.23 mg/kg. I is significantly less efficacious than melatonin in constricting human coronary artery.
Bioorganic & Medicinal Chemistry published new progress about Homo sapiens. 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Reference of 6942-39-8.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary