Choi, Young Lok; Kim, Joa Kyum; Choi, Sang-Un; Min, Yong-Ki; Bae, Myung-Ae; Kim, Bum Tae; Heo, Jung-Nyoung published the artcile< Synthesis of aristolactam analogues and evaluation of their antitumor activity>, Category: bromides-buliding-blocks, the main research area is aristolactam analog library preparation antitumor.
A series of natural aristolactams and their analogs have been prepared and evaluated for antitumor activity against human cancer cells, including multi-drug resistant cell lines. Naturally occurring aristolactams, such as aristolactam BII (cepharanone B), aristolactam BIII, aristolactam FI (piperolactam A), N-Me piperolactam A, and sauristolactam showed moderate antitumor activities in selected cell lines. However, several synthetic aristolactam derivatives (e.g. I) exhibited potent antitumor activities against a broad array of cancer cell lines with GI50 values in the submicromolar range.
Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 337536-14-8 belongs to class bromides-buliding-blocks, and the molecular formula is C9H8Br2O2, Category: bromides-buliding-blocks.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary