Chen, Xiang-Yu; Zhao, Kun; Liu, Qiang; Zhi, Ying; Ward, James; Rissanen, Kari; Enders, Dieter published the artcile< N-heterocyclic carbene-catalyzed 1,6-addition of homoenolate equivalent intermediates: asymmetric synthesis of nonspirocyclic quaternary oxindoles>, Related Products of 3893-18-3, the main research area is nonspirocyclic diarylmethyl isoxazolyl oxindole ester preparation stereoselective; quinone methide cinnamaldehyde isatin isoxazole cycloaddition heterocyclic carbene catalyst.
Although there is a growing interest in developing asym. 1,6-addition reactions of carbon nucleophiles to Michael acceptors, the corresponding 1,6-addition of homoenolates remains an unsolved problem. Currently, the N-heterocyclic carbene (NHC)-catalyzed cycloadditions of homoenolate equivalent intermediates have achieved widespread success. However, considerable limitations still exist for the linear reactions with electron-deficient alkenes, which are limited to 1,4-Michael acceptors. This report presents the first NHC-catalyzed asym. homoenolate addition of enals to 1,6-Michael acceptors. The strategy leads to the challenging nonspirocyclic 3,3-disubstituted oxindoles with two adjacent stereocenters, a quaternary and a trisubstituted one, in good yields and high stereoselectivities with a wide variety of substrates.
CCS Chemistry published new progress about Cycloaddition reaction catalysts. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Related Products of 3893-18-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary