Chang, Dong-Jo; Yoon, Eun-Young; Lee, Geon-Bong; Kim, Soon-Ok; Kim, Wan-Joo; Kim, Young-Myeong; Jung, Jong-Wha; An, Hongchan; Suh, Young-Ger published their research in Bioorganic & Medicinal Chemistry Letters on August 1 ,2009. The article was titled 《Design, synthesis and identification of novel colchicine-derived immunosuppressant》.Computed Properties of C9H8BrNO4 The article contains the following contents:
Colchicine-derived nitrate esters I [R = MeO, SMe, Me2N; R1 = O2NO(CH2)3, 3-(O2NOCH2)C6H4, 4-(O2NOCH2)C6H4; R2 = H, Me] and II (R3, R4, R5 = H, MeO, F, Cl, Br, I, NC, O2N, Ph) are prepared as potential immunosuppressant agents and tested for their inhibition of the allogenic mixed-lymphocyte reaction. The cytotoxicities, inhibition of NO production, and inducible nitric oxide synthase and tumor necrosis factor-α levels for I [R = MeS; R1 = O2NO(CH2)3, 3-(O2NOCH2)C6H4] are determined; the inhibition of lymphoproliferation by I [R = MeS; R1 = O2NO(CH2)3, 3-(O2NOCH2)C6H4, 4-(O2NOCH2)C6H4; R2 = H] and by II (R3 = R4 = H; R5 = F), II (R3 = Cl; R4 = R5 = H), II (R3 = R4 = H; R5 = Cl), and II (R3 = O2N; R4 = R5 = H) are also determined The cytotoxicity of II (R3 = Cl; R4 = R5 = H) and its effectiveness in increasing skin allograft survival are determined and compared to that of cyclosporin A. After reading the article, we found that the author used Methyl 5-(bromomethyl)-2-nitrobenzoate(cas: 88071-91-4Computed Properties of C9H8BrNO4)
Methyl 5-(bromomethyl)-2-nitrobenzoate(cas: 88071-91-4) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Computed Properties of C9H8BrNO4
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary