Capel, Estefania; Luis-Barrera, Javier; Sorazu, Ana; Uria, Uxue; Prieto, Liher; Reyes, Efraim; Carrillo, Luisa; Vicario, Jose L. published the artcile< Transannular Approach to 2,3-Dihydropyrrolo[1,2-b]isoquinolin-5(1H)-ones through Bronsted Acid-Catalyzed Amidohalogenation>, HPLC of Formula: 6942-39-8, the main research area is pyrroloisoquinolinone preparation; benzo fused ene lactam amidohalogenation elimination Bronsted acid catalyst.
A transannular approach has been developed for the construction of pyrrolo[1,2-b]isoquinolinones I (R1 = H, F, Cl, Me, OMe, etc.; R2 = H, F, etc.; R3 = H, Me, etc.; R4 = H, F) starting from benzo-fused nine-membered enelactams II. This process takes place in the presence of a halogenating agent and under Bronsted acid catalysis and proceeds via a transannular amidohalogenation, followed by elimination. The reaction has been found to be wide in scope, enabling the formation of a variety of tricyclic products I in good overall yield, regardless of the substitution pattern in the initial lactam substrate. The reaction has also been applied to the total synthesis of a reported topoisomerase I inhibitor and to the formal synthesis of rosettacin. Further extension of this methodol. allows the preparation of 10-iodopyrrolo[1,2-b]isoquinolinones III (R1 = H, Me; R2 = H, F; R3 = H, F, Me, OMe) by using an excess of halogenating agent and these compounds can be further manipulated through standard Suzuki coupling chem. into a variety of 10-aryl-substituted pyrrolo[1,2-b]isoquinolinones IV.
Journal of Organic Chemistry published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, HPLC of Formula: 6942-39-8.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary