Category: bromides-buliding-blocksIn 2019 ,《Thinking Outside the “”Blue Box””: Induced Fit within a Unique Self-Assembled Polycationic Cyclophane》 was published in Journal of the American Chemical Society. The article was written by Blanco-Gomez, Arturo; Fernandez-Blanco, Angel; Blanco, Victor; Rodriguez, Jaime; Peinador, Carlos; Garcia, Marcos D.. The article contains the following contents:
We present herein the development of a new polycationic mol. receptor, inspired by the ubiquitous cyclobis(paraquat-p-phenylene)cyclophane (“”blue box””). Our analog, the “”white box””, has been easily self-assembled on a preparative scale in water, using a template-assisted process by acyl hydrazone bonding of complementary bis(pyridinium)xylylene tweezers, followed by kinetic trapping of the empty receptor. The obtained macrocycle was found to display a marked pH responsiveness in water, because of an abnormal acidity of the amide protons within its structure. Consequently, and because of the concurrence of rotational isomerism under acidic conditions (fixed at higher pH values), the compound was found to display a dual behavior as a conformationally locked/flexible mol. host, being able to recognize appropriate aromatic substrates, in a lock and key or induced fit fashion, by a conjunction of π-π, C-H···π, and, crucially, the hydrophobic effect. In addition to this study using 1,4-Bis(bromomethyl)benzene, there are many other studies that have used 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Category: bromides-buliding-blocks) was used in this study.
1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary