Application of 17696-11-6In 2021 ,《Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Protein》 appeared in Journal of the American Chemical Society. The author of the article were Besten, Willem den; Verma, Kshitij; Yamazoe, Sayumi; Blaquiere, Nicole; Phung, Wilson; Izrael-Tomasevic, Anita; Mulvihill, Melinda M.; Helgason, Elizabeth; Prakash, Sumit; Goncharov, Tatiana; Vucic, Domagoj; Dueber, Erin; Fairbrother, Wayne J.; Wertz, Ingrid; Yu, Kebing; Staben, Steven T.. The article conveys some information:
We hypothesized that the proximity-driven ubiquitylation of E3-interacting small mols. could affect the degradation of E3 ubiquitin ligases. A series of XIAP BIR2 domain-binding small mols. was modified to append a nucleophilic primary amine. This modification transforms XIAP binders into inducers of XIAP degradation The degradation of XIAP is E1- and proteasome-dependent, dependent on the ligase function of XIAP, and is rescued by subtle modifications of the small mol. that would obviate ubiquitylation. We demonstrate in vitro ubiquitylation of the small mol. that is dependent on its interaction with XIAP. Taken together, these results demonstrate the designed ubiquitylation of an engineered small mol. and a novel approach for the degradation of E3 ubiquitin ligases. In the part of experimental materials, we found many familiar compounds, such as 8-Bromooctanoic acid(cas: 17696-11-6Application of 17696-11-6)
8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Application of 17696-11-6
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary