《Total Synthesis of (+)-Oxo-tomaymycin》 was written by Benedetti, Francoise; Perrin, Marc-Antoine; Bosc, Sebastien; Chouteau, Franck; Champion, Nicolas; Bigot, Antony. COA of Formula: C20H20BrPThis research focused ontomaymycin oxo total synthesis chemoselective reduction cyclization. The article conveys some information:
(+)-Oxo-tomaymycin (I), a naturally occurring substance of the pyrrolo-1,4-benzodiazepine family, was synthesized using a short and efficient route. The key construction of the seven-membered ring by amide bond formation was realized via a chemoselective Aryl-NO2 reduction using TiCl3 under acidic conditions, followed by a spontaneous cyclization. This synthesis was easily scaled up to 80 g, and it should be amenable to the production of larger quantities.Ethyltriphenylphosphonium bromide(cas: 1530-32-1COA of Formula: C20H20BrP) was used in this study.
Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.COA of Formula: C20H20BrP
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary