Baiula, Monica; Cirillo, Martina; Martelli, Giulia; Giraldi, Valentina; Gasparini, Elisa; Anelli, Alessandro Claudio; Spampinato, Santi Mario; Giacomini, Daria published their research in ACS Pharmacology & Translational Science in 2021. The article was titled 《Selective Integrin Ligands Promote Cell Internalization of the Antineoplastic Agent Fluorouracil》.Recommanded Product: 5437-45-6 The article contains the following contents:
Drug conjugates consisting of an antineoplastic drug and a targeting receptor ligand could be effective to overcome the heavy side effects of unselective anticancer agents. To address this need, we report here the results of a project aimed to study agonist and antagonist integrin ligands as targeting head of mol. cargoes for the selective delivery of 5-fluorouracil (5-FU) to cancer or noncancer cells. Initially, two fluorescent β-lactam-based integrin ligands were synthesized and tested for an effective and selective internalization mediated by α4β1 or α5β1 integrins in Jurkat and K562 cells, resp. No cellular uptake was observed for both fluorescent compounds in HEK293 noncancerous control cells. Afterward, three conjugates composed of the β-lactam-based integrin ligand, suitable linkers, and 5-FU were realized. The best compound E (I), acting as α5β1 integrin agonist, is able to selectively deliver 5-FU into tumor cells, successfully leading to cancer cell death. The results came from multiple reactions, including the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Recommanded Product: 5437-45-6)
Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.Recommanded Product: 5437-45-6
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary