Badir, Shorouk O.; Sim, Jaehoon; Billings, Katelyn; Csakai, Adam; Zhang, Xuange; Dong, Weizhe; Molander, Gary A. published the artcile< Multi-functional Building Blocks Compatible with Photo-redox-Mediated Alkylation for DNA-Encoded Library Synthesis>, Quality Control of 20776-50-5, the main research area is amino acid DNA synthesis coupling alkylation silylamine aminomethylation; alkyl bromide cross coupling alkylation silylamine DNA synthesis; photochem redox alkylation DNA encoded library synthesis.
DNA-encoded library (DEL) technol. has emerged as a novel interrogation modality for ligand discovery in the pharmaceutical industry. Given the increasing demand for a higher proportion of C(sp3)-hybridized centers in DEL platforms, a photoredox-mediated cross-coupling and defluorinative alkylation process is introduced using com. available alkyl bromides and structurally diverse α-silylamines. Notably, no protecting group strategies for amines are necessary for the incorporation of a variety of amino-acid-based organo-silanes, providing crucial branching points for further derivatization.
Organic Letters published new progress about Alkylation. 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Quality Control of 20776-50-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary