《Synthesis and biological evaluation of substituted amide derivatives of C4-ageratochromene dimer analog》 was written by Agarwal, Karishma; Gupta, Kratika; Sharma, Kriti; Khanka, Sonu; Singh, Shilpi; Singh, Jyoti; Trivedi, Laxmikant; Vasdev, Prema G.; Luqman, Suaib; Khan, Feroz; Singh, Divya; Gupta, Atul. Computed Properties of C7H13BrO2 And the article was included in Bioorganic & Medicinal Chemistry Letters in 2021. The article conveys some information:
Substituted amide derivatives of C4-ageratochromene dimer analog were synthesized through structural modification of precocene-I, isolated from the essential oil of Ageratum conyzoides L. The target compounds were evaluated for their bone-forming effect using osteoblast differentiation assay. Seven compounds presented good activity within 1 pM-1 nM concentration At 1 pM concentration, the most active compound (I) showed effective mineralization of osteoblast cells along with expression of osteogenic marker genes viz RUNX 2, BMP-2, and type 1 collagen (Type-1 col) without any toxicity towards osteoblast cells. Single crystal X-ray anal. of two compounds revealed that the core nucleus of these mols. bear Ph rings in a trans-stilbenoid system and had a good structural correlation with 17β-estradiol and diethylstilbestrol (DES). In-silico study about I showed its structural complementarities with the LBD of estrogen receptor (ER) which indicated possible ER-mediated activity of compounds After reading the article, we found that the author used Ethyl 5-bromovalerate(cas: 14660-52-7Computed Properties of C7H13BrO2)
Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Computed Properties of C7H13BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary