《General and selective syn-carboxylation-trifluoromethylation of terminal alkynes: application to the late-stage modification of dehydrocholic acid》 was written by Zhang, Song-Lin; Xiao, Chang; Wan, Hai-Xing; Zhang, Xiaoming. Formula: C7H5BrO2This research focused ontrifluoromethyl enol carboxylic ester preparation regioselective diastereoselective; terminal aryl alkyne carboxylic acid syn carboxylation trifluoromethylation. The article conveys some information:
A general and selective method is developed that allows difunctionalization of terminal alkynes by a Cu(III)-CF3 complex and a carboxylic acid regioselectively and with unusual syn-stereochem. This method is broadly applicable to various carboxylic acids and terminal alkynes, producing a range of biol. active trifluoromethyl enol carboxylic esters I (Ar = 4-ClC6H4, 4-EtC6H4, Ph, etc.; R = tBu, Bu, 4-BrC6H4, etc.). The synthetic potential of this method is further demonstrated by the late-stage functionalization of a complex pharmaceutical compound dehydrocholic acid. In the experimental materials used by the author, we found 4-Bromobenzoic acid(cas: 586-76-5Formula: C7H5BrO2)
4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Formula: C7H5BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary