Zhang, Kaiheng; Sheng, Xiang; Deiana, Luca; Svensson Grape, Erik; Ken Inge, A.; Himo, Fahmi; Cordova, Armando published the artcile< Solvent Dependency in Stereoselective δ-Lactam Formation of Chiral α-Fluoromalonate Derivatives: Stereodivergent Synthesis of Heterocycles with Fluorine Containing Stereocenters Adjacent to Tertiary Stereocenters>, SDS of cas: 3893-18-3, the main research area is bicyclic lactam stereoselective preparation.
The discovery and investigation of solvent dependency in stereoselective intramol. amidation of chiral 5-aminofunctionalized-2-fluoromalonate ester derivatives, which gave access to highly functionalized δ-lactams with a quaternary fluorine-containing stereocenter was disclosed. Exptl. work together with d. functional theory calculations led to understanding of how to direct and switch the stereochem. outcome of the stereoselective δ-lactam formation. The merging of this solvent-dependent stereoselective switch with asym. catalysis and cascade reactions gave access to an unprecedented strategy for stereodivergent synthesis of all possible stereoisomers of fluorine-containing stereocenters adjacent to tertiary stereocenters of a wide range of heterocyclic compounds with 95->99% ee in one-pot. It was also useful for application in total synthesis of fluorine-containing pharmaceuticals.
Advanced Synthesis & Catalysis published new progress about Amidation (intramol.). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, SDS of cas: 3893-18-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary