Zhang, Hui; Li, Weishuang; Hu, Xu-Dong; Liu, Wen-Bo published the artcile< Enantioselective Synthesis of Fused Isocoumarins via Palladium-Catalyzed Annulation of Alkyne-Tethered Malononitriles>, Category: bromides-buliding-blocks, the main research area is isocoumarin preparation; phenylalkynyl malononitrile palladium catalyst enantioselective tandem oxypalladation intramol cycloaddition.
An enantioselective palladium-catalyzed annulation of alkyne-tethered malononitriles for the synthesis of 3,4-ring-fused isocoumarins were described. This cascade strategy involved oxypalladation of ortho-alkynylbenzoates and desymmetrizing addition onto one cyano group of the pendant malononitriles, which enabled the concurrent construction of two rings and an all-carbon quaternary stereocenter in a single operation.
Journal of Organic Chemistry published new progress about Aliphatic nitriles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Category: bromides-buliding-blocks.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary