Yeh, Chien-Hung; Chen, Wei-Chen; Gandeepan, Parthasarathy; Hong, Ya-Chun; Shih, Cheng-Hung; Cheng, Chien-Hong published the artcile< RhIII-catalyzed dual directing group assisted sterically hindered C-H bond activation: a unique route to meta and ortho substituted benzofurans>, Synthetic Route of 188813-04-9, the main research area is internal alkyne hydroxyphenyloxime ether regioselective CH activation heterocyclization rhodium; benzofuran regioselective directing group assisted preparation mol crystal structure; rhodium regioselective sterically hindered CH activation heterocyclization catalyst.
A new strategy for the synthesis of highly substituted benzofurans, e.g., I (X-rays single crystal structure shown), from meta-substituted hydroxybenzenes and alkynes via a rhodium(III)-catalyzed activation of a sterically hindered C-H bond is demonstrated. A possible mechanism involving dual directing group assisted ortho C-H bond activation is proposed.
Organic & Biomolecular Chemistry published new progress about Alkynes, internal Role: RCT (Reactant), RACT (Reactant or Reagent). 188813-04-9 belongs to class bromides-buliding-blocks, and the molecular formula is C8H7BrO, Synthetic Route of 188813-04-9.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary