Ye, Zhi-Peng; Hu, Yuan-Zhuo; Guan, Jian-Ping; Chen, Kai; Liu, Fang; Gao, Jie; Xiao, Jun-An; Xiang, Hao-Yue; Chen, Xiao-Qing; Yang, Hua published the artcile< Photocatalytic Cyclization/Defluorination Domino Sequence to Access 3-Fluoro-1,5-dihydro-2H-pyrrol-2-one Scaffold>, Application In Synthesis of 3959-07-7, the main research area is fluoro dihydropyrrolone preparation photochem; allylbromodifluoroacetamide cyclic secondary amine tandem cyclization defluorination.
Herein an unprecedented photoinduced cyclization/defluorination domino process of N-allylbromodifluoroacetamide with cyclic secondary amines is reported. Consequently, a wide array of valuable 3-fluoro-1,5-dihydro-2H-pyrrol-2-ones I (R = Ph, 4-i-PrC6H4, Bn, etc.; X = O, N(Boc), N(COMe), etc.; R1 = H, Me) were facilely prepared from readily available starting materials under mild conditions. Preliminary mechanistic investigations suggest that a radical chain propagation and amine-promoted defluorination pathway are presumably involved in this transformation.
Organic Letters published new progress about Acetamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (N-allylbromodifluoro). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application In Synthesis of 3959-07-7.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary