Wu, Jing; Zheng, Chunming; Li, Bryan; Hawkins, Joel M.; Scott, Susannah L. published the artcile< Efficient, continuous N-Boc deprotection of amines using solid acid catalysts>, Name: 4-Bromobenzylamine, the main research area is amine preparation; tert butyloxycarbonyl amine deprotection solid acid catalyst.
The use of simple solid Bronsted acid catalysts to achieve continuous N-Boc deprotection of amines, e.g., tert-Bu 2-oxopiperidine-1-carboxylate without addnl. workup steps has been described. Using THF as the solvent, H-BEA zeolite affords high yields of a variety of aromatic and aliphatic amines, e.g., 2-piperidinone often in residence times of less than a minute at 140°C. The same catalyst/solvent combination is ineffective in batch conditions, due to the much lower temperature of refluxing THF. Boc-protected p-chloroaniline was deprotected with a throughput of 18 mmol p-chloroaniline per h per gcat, sustained over 9 h. The active sites of the zeolite do not appear to be directly associated with the Al framework substitution in the micropores, since partially ion-exchanged Na/H-BEA shows activity similar to H-BEA. The strong Bronsted acid sites (framework [Si(OH)Al]), are likely poisoned by the amine product. Moderate Bronsted acid sites associated with silanol defects near Al on or near the external surface (and not susceptible to Na+-exchange) are presumably the active sites, since they are not poisoned even by more basic aliphatic amines.
Reaction Chemistry & Engineering published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Name: 4-Bromobenzylamine.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary