Wolff, Oliver; Waldvogel, Siegfried R. published the artcile< 3-substituted phthalic acid derivatives by Sonogashira coupling reaction>, Computed Properties of 82-73-5, the main research area is phthalic acid substituted preparation Sonogashira coupling reaction.
Phthalic acid derivatives with carbon substituents in position 3 are easily accessible by Sonogashira coupling reaction of the corresponding bromo derivative For reasonable conversions the phthaloyl moiety is masked as the N-phenylphthalimide, which can smoothly be converted into other phthalic acid derivatives For example, stirring 3-bromo-N-phenylphthalimide with oct-1-yne in DMF in the presence of Et3N, CuI, and bis(triphenylphosphine)palladium dichloride at 80° for 16 h gave 91% 3-(oct-1-ynyl)-N-phthalimide.
Synthesis published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Computed Properties of 82-73-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary