Wang, Fenghua; Chen, Cheng; Yang, Kailin; Xu, Yang; Liu, Xiaomei; Gao, Fan; Liu, He; Chen, Xia; Zhao, Qi; Liu, Xiang; Cai, Yan; Yang, Haitao published the artcile< Michael Acceptor-Based Peptidomimetic Inhibitor of Main Protease from Porcine Epidemic Diarrhea Virus>, HPLC of Formula: 405931-46-6, the main research area is preparation Michael acceptor peptidomimetic porcine epidemic diarrhea virus protease.
Porcine epidemic diarrhea virus (PEDV) causes high mortality in pigs. PEDV main protease (Mpro) plays an essential role in viral replication. We solved the structure of PEDV Mpro complexed with peptidomimetic inhibitor N3 carrying a Michael acceptor warhead, revealing at. level interactions. We further designed a series of 17 inhibitors with altered side groups. Inhibitors M2 and M17 demonstrated enhanced specificity against PEDV Mpro. These compounds have potential as future therapeutics to combat PEDV infection.
Journal of Medicinal Chemistry published new progress about Antiviral agents. 405931-46-6 belongs to class bromides-buliding-blocks, and the molecular formula is C8H8BrF, HPLC of Formula: 405931-46-6.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary