Tyler, Jasper L.; Noble, Adam; Aggarwal, Varinder K. published the artcile< Strain-Release-Driven Friedel-Crafts Spirocyclization of Azabicyclo[1.1.0]butanes>, Recommanded Product: Isopropyltriphenylphosphonium bromide, the main research area is tertiary butoxy carbonyl azetidino spiro tetralin preparation regioselective DFT; alkylazetidine preparation Friedel Crafts spirocyclization tetrafluoroboric acid etherate catalyst; azabicyclobutane carbinol preparation alkyl halide alkylation; azabicylo[1.1.0]butanes; azetidines; dearomatization; spiro compounds; strained molecules.
The strain-release-driven Friedel-Crafts spirocyclization of azabicyclo[1.1.0]butane-tethered (hetero)aryls I (R = H, Me, Bn, allyl, triethylsilyl; R1 = Ph, 2-naphthyl, benzothiophen-2-yl, etc.) for the synthesis of a unique library of azetidine spiro-tetralins e.g., II was reported. The reaction was discovered to proceed through an unexpected interrupted Friedel-Crafts mechanism, generating a highly complex azabicyclo[2.1.1]hexane scaffold. This dearomatized intermediate, formed exclusively as a single diastereomer, can be subsequently converted to the Friedel-Crafts product upon electrophilic activation of the tertiary amine, or trapped as a Diels-Alder adduct in one-pot. The rapid assembly of mol. complexity demonstrated in these reactions highlights the potential of the strain-release-driven spirocyclization strategy to be utilized in the synthesis of medicinally relevant scaffolds.
Angewandte Chemie, International Edition published new progress about Aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1530-33-2 belongs to class bromides-buliding-blocks, and the molecular formula is C21H22BrP, Recommanded Product: Isopropyltriphenylphosphonium bromide.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary