Singh, Avineesh; Patel, Vijay K.; Rajak, Harish published the artcile< Appraisal of pyrrole as connecting unit in hydroxamic acid based histone deacetylase inhibitors: Synthesis, anticancer evaluation and molecular docking studies>, Reference of 3893-18-3, the main research area is pyrrole hydroxamic acid preparation SAR antitumor mol docking human; histone deacetylase inhibitor.
SAHA and its synthetic analogs has demonstrated potent antitumor activity against numerous human cancer lines and different classes of HDACs. The objective of present studies was to incorporate pyrrole as connecting unit in hydroxamic acid based HDAC inhibitors for their anticancer evaluation and mol. docking studies. A series of novel 4-substituted Me 6-(3-acetyl-2-methyl-1H-pyrrol-1-yl)hexanoate I (R = Ph, 4-ClC6H4, 4-BrC6H4, etc.) and 4-substituted 6-(3-acetyl-2-methyl-1H-pyrrol-1-yl)-N-hydroxyhexanamide II were synthesized and were evaluated for their anticancer activity using in-vitro method against leukemia (K-562), lung (A-549), breast (MCF-7), and cervical (HeLa) human cancer cell lines using Sulforhodamine B (SRB) assay method, HDAC1 and HDAC6 inhibitory assay and binding mode anal. using mol. docking studies. Interestingly, p-nitro-substituted mol. produced a most active derivative in the series. The in-vitro anticancer study of synthesized compounds indicated that the unsubstituted Ph derivative, II (R = Ph) have moderate antitumor activity against K-562 human leukemia cell line. Substitution at 4-Ph ring with weak and moderate electron withdrawing groups, such as fluoro, chloro, and bromo potentiated the cytotoxic activity. Compounds II were docked against different HDAC proteins to determine the exact binding mode and orientation. These studies can be further employed for the design and development of novel SAHA analogs with promising anticancer activity.
Journal of Molecular Structure published new progress about Antitumor agents. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Reference of 3893-18-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary