Shah, Shalini; Goyal, Anju published the artcile< Synthesis and antimicrobial activity of some n'-(substituted benzylidene)-2-(7-bromo-phenylquinazolin-4-yloxy) acetohydrazide derivatives>, Related Products of 20776-50-5, the main research area is benzylidene bromophenylquinazolinyloxy acetohydrazide preparation antibacterial antifungal activity.
The title compounds were prepared by the reaction of bromoanthranilic acid with benzoyl chloride which gave 7-bromo-2-phenyl-4H-benzo(1,3)oxazin-4-one, further on reaction with formamide gave 7-bromo-2-phenylquinazolin-4(3H)-one. The esterification product of 7-bromo-2-phenylquinazolin-4(3H)-one reacted with hydrazine-hydrate gave (7-bromo-2-phenylquinazolin-4yloxy)acetohydrazide. The sub stituted benzaldehyde RCHO on reaction with (7-bromo-2-phenylquinazolin-4-yloxy)acetohydrazide yielded N’-(sub stituted benzylidene)-2-(7-bromo-2-phenylquinazolin-4-yloxy) acetohydrazide I (R = Cl, OH, NO2; R1 = MeO, NO2, Cl; R2 = Cl, MeO, F, OH, NO2; R3 = MeO). All synthesized derivative compounds I were evaluated for their in vitro antimicrobial activities using the disk diffusion technique. All the synthesized compounds exhibit antimicrobial activity and the compounds I (R = NO2; R1 = NO2; R2 = F, NO2) have a broad spectrum of activity at 50μg/mL.
International Journal of Pharmaceutical Sciences and Research published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Related Products of 20776-50-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary