Recommanded Product: 3395-91-3In 2016 ,《Novel 2,4-thiazolidinedione analogues as cytotoxic agents: synthesis and biological screening》 was published in International Journal of Pharmaceutical Research and Bio-Science. The article was written by Shah, Dhaval G.; Patel, Laxman J.. The article contains the following contents:
Novel thiazolidinedione derivatives I (R1 = H, CH2CO2H, CH2CO2Et, etc.; R2 = benzoyl, 2,3-dichlorobenzoyl, 2,4-dichlorobenzoyl, etc.) were synthesized via reaction of N-benzoyl substituted aryl alkyl halide with N-substituted 2,4-thiazolidinedione derivatives and screened for their in vitro cytotoxic activity by MTT assay. The cell lines used were MCF 7 (Breast cancer cell), HELA (Cervical cancer cell line), HEK (Normal epidermal kidney cell line) HEP (Laryngeal cancer cell line) MDA MB 468 (Breast cancer cell line). Screening results showed moderate to good cytotoxic activity for all the compounds Compound I (R1 = CH2CO2H; R2 = 4-chlorobenzoyl) (IC50 = 3.63 μM, HEP, IC50 = 1.07 μM, HEK) and compound I (R1 = CH2CO2H; R2 = 2,3-dichlorobenzoyl) (IC50 = 1.09 μM, HELA, IC50 = 1.989 μM, M468, IC50 = 2.5 μM, MCF7) were found to be most active compared to standard methotrexate (IC50 = 0.22 μM HEP, IC50 = 0.072 μM HEK, IC50 = 0.102 μM HELA, IC50 = 0.152 μM M468, IC50 = 0.100 μM MCF7). Structure activity relationship of synthesized analogs suggested that the attachment of electron withdrawing groups like chloro at R2 position and acetyl group at R1 gave better cytotoxic activity. Activity by hydrogen and acetyl substitution at R1 position linked with N-substituted 2,4-thiazolidinedione scaffold gave better activity in the order of H > CH2COOH. These findings may impart new direction to medicinal chemists and biochemists for further investigations of 2,4-thiazolidinedione containing cytotoxic agents. In the experiment, the researchers used many compounds, for example, Methyl 3-bromopropanoate(cas: 3395-91-3Recommanded Product: 3395-91-3)
Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: 3395-91-3
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary