Rajput, Santosh; Gardner, Christopher R.; Failes, Timothy W.; Arndt, Greg M.; Black, David StC.; Kumar, Naresh published the artcile< Synthesis and anticancer evaluation of 3-substituted quinolin-4-ones and 2,3-dihydroquinolin-4-ones>, Quality Control of 14062-30-7, the main research area is antitumor quinolinone dihydroquinolinone preparation; Anticancer; Dihydroquinolin-4-one; Quinolin-4-one.
A series of 3-aryl-5,7-dimethoxyquinolin-4-ones I [R1 = Ph, 4-BrC6H4, 4-MeC6H4, etc.] and 3-aryl-5,7-dimethoxy-2,3-dihydroquinolin-4-ones II [ R2 = Ph, 4-BrC6H4, 4-MeC6H4, etc.] were synthesized in good yields. Demethylation under a range of conditions afforded the corresponding 5-hydroxy and 5,7-dihydroxy derivatives Biol. evaluation against a range of cancer cells lines showed that the quinolin-4-one scaffold was more cytotoxic than the reduced 2,3-dihydroquinolin-4-one scaffold. The most active monohydroxy compound demonstrated 85.9-99% reduction in cell viability against the cell lines tested.
Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 14062-30-7 belongs to class bromides-buliding-blocks, and the molecular formula is C10H11BrO2, Quality Control of 14062-30-7.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary