Pave, Gregoire; Leger, Jean-Michel; Jarry, Christian; Viaud-Massuard, Marie-Claude; Guillaumet, Gerald published the artcile< Enantioselective synthesis of spirocyclic aminochroman derivatives according to the CN(R,S) strategy>, COA of Formula: C7H7BrO2, the main research area is asym synthesis spirocyclic aminochroman derivative cyano phenyl oxazolopiperidine substitution; crystal structure absolute configuration aminochroman derivative benzopyran piperidine.
Enantiomerically pure (3’R)- and (3’S)-3′,4′-dihydrospiro[piperidine-2,3′(2’H)-benzopyran]s I (R = H) and II (R = H) were successfully synthesized according to the CN(R,S) methodol. with the aim of serving as a pattern for the generation of related spirocyclic compounds Two different synthetic pathways were studied starting from 2-cyano-6-phenyloxazolopiperidine III. One of them was selected and used for the preparation of amines I (R = OMe) and II (R = OMe) starting from III and IV, resp. The enantiomeric purity of all final aminochroman derivatives was determined by capillary electrophoresis using β-cyclodextrin as the chiral selector.
Journal of Organic Chemistry published new progress about Absolute configuration. 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, COA of Formula: C7H7BrO2.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary