Nozawa-Kumada, Kanako; Matsuzawa, Yuta; Ono, Kanako; Shigeno, Masanori; Kondo, Yoshinori published an article in 2021. The article was titled 《Copper-catalyzed aerobic double functionalization of benzylic C(sp3)-H bonds for the synthesis of 3-hydroxyisoindolinones》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Synthetic Route of C7H5BrO The information in the text is summarized as follows:
An aerobic copper-catalyzed synthesis of 3-hydroxyisoindolinones I (R1 = Ph, 3-thienyl, OMe, etc., R2 = Me, Ph, cyclopropyl, etc., R3 = Me, F, Cl, H, R4 = H, MeO, CF3, R3R4 = OCH2O) was developed via the benzylic double C(sp3)-H functionalization of 2-alkylbenzamides II. In this reaction, mol. oxygen was used as both an oxidant for C(sp3)-H functionalization and an oxygen source. The method can be extended to diverse benzylic C(sp3)-H bonds and shows excellent functional group tolerance. The results came from multiple reactions, including the reaction of o-Bromobenzaldehyde(cas: 6630-33-7Synthetic Route of C7H5BrO)
o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Synthetic Route of C7H5BrOSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary