Moir, Michael; Lane, Samuel; Montgomery, Andrew P.; Hibbs, David; Connor, Mark; Kassiou, Michael published the artcile< The discovery of a potent and selective pyrazolo-[2,3-e]-[1,2,4]-triazine cannabinoid type 2 receptor agonist>, Related Products of 81107-97-3, the main research area is cannabinoid type 2 receptor structure activity relationship; CB(2)R selective; Cannabinoid; Docking; Pyrazolotriazine; Structure-activity relationship study; Synthesis.
The development of selective CB2 receptor agonists is a promising therapeutic approach for the treatment of inflammatory diseases, without CB1 receptor mediated psychoactive side effects. Preliminary structure-activity relationship studies on pyrazoylidene benzamide agonists revealed the -ylidene benzamide moiety was crucial for functional activity at the CB2 receptor. A small library of compounds with varying linkage moieties between the pyrazole and substituted Ph group has culminated in the discovery of a potent and selective pyrazolo-[2,3-e]-[1,2,4]-triazine agonist 19 (CB2R EC50 = 19 nM, CB1R EC50 > 10μM). Docking studies have revealed key structural features of the linkage group that are important for potent functional activity.
European Journal of Medicinal Chemistry published new progress about Cannabinoid receptor 1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Related Products of 81107-97-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary