Mo, Di-Wei; Dong, Shuai; Sun, Haiyan; Chen, Jia-Sheng; Pang, Jian-Xin; Xi, Bao-Min; Chen, Wen-Hua published the artcile< Synthesis and potent inhibitory activities of carboxybenzyl-substituted 8-(3-(R)-aminopiperidin-1-yl)-7-(2-chloro/cyanobenzyl)-3-methyl-3,7-dihydro-purine-2,6-diones as dipeptidyl peptidase IV (DPP-IV) inhibitors>, Quality Control of 85070-57-1, the main research area is dihydropurinedione derivative preparation dipeptidyl peptidase IV inhibitory activity; 3-Methyl-3,7-dihydro-purine-2,6-dione; Diabetes; Dipeptidyl peptidase IV inhibitor; Inhibitory activity; Synthesis.
Fourteen 3-methyl-3,7-dihydro-purine-2,6-dione derivatives bearing carboxybenzyl and 2-chloro/cyanobenzyl groups at the N-1 and N-7 positions, resp., were synthesized as dipeptidyl peptidase IV (DPP-IV) inhibitors. These compounds were characterized on the basis of NMR (1H and 13C) and ESI MS data. In vitro bioassay indicates that most of these compounds showed moderate to good inhibitory activities against DPP-IV. Among them, compound I (IC50 = 36 nM) exhibited comparable activity with a pos. control, Sitagliptin (IC50 = 16 nM). In addition, the structure-activity relationship of these compounds is also briefly discussed.
Bioorganic & Medicinal Chemistry Letters published new progress about Antidiabetic agents. 85070-57-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H8BrFO2, Quality Control of 85070-57-1.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary