Martinelli, Joseph R.; Watson, Donald A.; Freckmann, Dominique M. M.; Barder, Timothy E.; Buchwald, Stephen L. published the artcile< Palladium-Catalyzed Carbonylation Reactions of Aryl Bromides at Atmospheric Pressure: A General System Based on Xantphos>, Quality Control of 639520-70-0, the main research area is heteroaryl aryl bromide chloride dimethylhydroxylamine hydrochloride cyclic aliphatic amine; methanol palladium Xantphos aminocarbonylation alkoxycarbonylation; Weinreb amide benzamide methyl ester preparation; aminocarbonylation alkoxycarbonylation catalyst palladium Xantphos.
A method for the Pd-catalyzed carbonylation of aryl bromides has been developed using Xantphos as the ligand. This method is effective for the direct synthesis of Weinreb amides, 1° and 2° benzamides, and Me esters from the corresponding aryl bromides at atm. pressure. In addition, a putative catalytic intermediate, (Xantphos)Pd(Br)benzoyl, was prepared and an X-ray crystal structure was obtained revealing an unusual cis-coordination mode of Xantphos in this palladium-acyl complex.
Journal of Organic Chemistry published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Quality Control of 639520-70-0.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary