Lux, Michaelyn C.; Boby, Melissa L.; Brooks, Joshua L.; Tan, Derek S. published the artcile< Synthesis of bicyclic ethers by a palladium-catalyzed oxidative cyclization-redox relay-π-allyl-Pd cyclization cascade reaction>, Application In Synthesis of 81107-97-3, the main research area is diastereoselective synthesis bicyclic ether; palladium catalyzed oxidative cyclization cascade bicyclic ether synthesis.
Bicyclic ether scaffolds are found in a variety of natural products and are of interest in probe and drug discovery. A palladium-catalyzed cascade reaction has been developed to provide efficient access to these scaffolds from readily available linear diene-diol substrates [e.g., I → II, (60% isolated) with complete cis-diastereoselectivity at ring junction and 4:1 dr (α/β) at vinyl side chain]. A Pd redox-relay process is used strategically to transmit reactivity between an initial oxypalladative cyclization and a subsequent π-allyl-Pd cyclization at remote sites. The reaction affords variety of bicyclic ether scaffolds with complete diastereoselectivity for cis-ring fusion.
Chemical Communications (Cambridge, United Kingdom) published new progress about Alkadienes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Application In Synthesis of 81107-97-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary